Interpersonal violence affects the lives of millions of children across the world. Up to 50% of all children aged 2 to 17 years are thought to have been affected by a form of violence (physical, sexual or emotional abuse) in the past year – the equivalent of 1 billion children. Schools are in a unique position to address and prevent violence against children. This handbook provides guidance for school officials and education authorities on how schools can embed violence prevention within their routine activities and across the points of interaction schools provide with children, parents and other community members. If implemented, the handbook will contribute much to helping achieve the Sustainable Development Goals and other global health and development goals.